Polyvinyl alcohol/soy protein isolate nanofibrous patch for wound-healing applications

Soy protein isolate (SPI), due to its biocompatibility, biodegradability, abundance and being inexpensive, is a suitable polymer for medical applications. In this study, electrospun nanofibrous mats (ENMs) and casting films (CFs), comprising polyvinyl alcohol (PVA)/SPI, were prepared and compared. Both crosslinked ENMs and CFs physical, chemical, mechanical, and biological properties were investigated for wound-healing applications. Considering the importance of exudate absorption by wound dressing the uptake test of all samples was performed in simulated exudate solution. The amount of absorbed exudate, water vapor transmission rate, and mechanical elongation for CFs were 69.243% ± 22.7, 266.7 g/m² day, and 2.0825% and increased to 383.33% ± 105.3, 1332.02 g/m² day, and 12.292% in the case of ENMs, respectively. There was no significant difference between cell supporting of the two samples due to similar composition and their non-toxic properties. The results showed that ENMs have promising potential in wound-healing applications.