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A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications
Pengzhong Shi1,2,3, Jianghui Qin1, Xiaoxiao Wu1
1School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering , Wenzhou Medical University , Wenzhou , Zhejiang Province 325035 , P. R. China.
ACS Applied Materials & Interfaces
|September 26, 2019
Summary
Scientists developed a versatile method to create protein capsules for various applications. These biocompatible capsules retain protein function, showing promise in drug delivery and tissue engineering.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Protein Engineering
Background:
- Proteins are crucial building blocks in life and material sciences.
- Protein capsules and protein-polymer conjugates are explored for drug delivery, catalysis, and cell mimicry.
- Existing methods for protein capsule fabrication can be limited by protein properties.
Purpose of the Study:
- To present a facile, universal, and efficient method for fabricating diverse protein capsules.
- To demonstrate that the fabricated capsules retain the original protein functionality.
- To explore the potential applications of these protein capsules.
Main Methods:
- Fabrication of protein capsules using a novel, universal method.
- Characterization of protein capsules using various analytical techniques.
- Assessment of protein functionality, including enzyme responsiveness and biocompatibility in vitro and in vivo.
Main Results:
- A universal and efficient method for fabricating diverse protein capsules was successfully developed.
- The method is independent of protein molecular weight, isoelectric points, wettability, and amino acid sequence.
- The protein capsules effectively stored original protein functionality, exhibiting enzyme responsiveness and good biocompatibility.
- In vitro and in vivo studies confirmed the biocompatibility of the protein capsules.
Conclusions:
- The developed method provides a facile and universal approach to create protein capsules.
- These protein capsules maintain inherent protein functions, demonstrating enzyme responsiveness and biocompatibility.
- Potential applications include drug delivery, tissue engineering, and catalysis, highlighting their versatility.
