Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

Area of Science:

• Biomaterials Science
• Nanotechnology
• Neuroscience

Background:

• Neurotrauma causes significant injury by increasing reactive oxygen and nitrogen species (RONS), leading to neuroinflammation.
• Conventional antioxidant bandages offer short-term protection against oxidative stress but lose efficacy quickly.
• Developing persistent and effective treatments for neurotrauma remains a critical challenge.

Purpose of the Study:

• To develop a nanozyme-based bandage with sustained catalytic activity for treating neurotrauma.
• To investigate the enhanced antioxidant and enzymatic properties of single-atom Pt/CeO2.
• To evaluate the efficacy of the nanozyme bandage in promoting neurotrauma wound healing and reducing inflammation.

Main Methods:

• Fabrication of a nanozyme bandage utilizing single-atom platinum (Pt) dispersed on cerium dioxide (CeO2) facets.
• Characterization of Pt/CeO2 structure, focusing on Pt distribution and CeO2 facet orientation.
• Assessment of scavenging activity against RONS and multienzyme activities compared to CeO2 clusters.
• Evaluation of catalytic activity duration and in vivo efficacy in a neurotrauma model.

Main Results:

• Single-atom Pt on CeO2 (111) facets significantly enhanced intrinsic catalytic activity.
• Pt/CeO2 exhibited 2-10 times higher RONS scavenging and 3-10 times higher multienzyme activities than CeO2 clusters.
• The nanozyme bandage maintained long-lasting catalytic activity for up to one month.
• In vivo studies demonstrated significant improvement in neurotrauma wound healing and reduced neuroinflammation.

Conclusions:

• Single-atom Pt/CeO2 nanozymes offer a promising strategy for persistent treatment of neurotrauma.
• The developed nanozyme bandage effectively mitigates oxidative stress and neuroinflammation.
• This approach represents a significant advancement in noninvasive neurotrauma therapy.