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[PROBLEMS OF USING FORENSIC MOLECULAR-GENETIC EXAMINATION IN CRIMINAL PROCEDURE OF UKRAINE].

Georgian medical news·2019
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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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[MORPHOLOGICAL CHARACTERISTICS OF THE THYROID GLAND OF MATURE RATS IN MODERATE DEGREE CHRONIC HYPERTHERMIA].

Y Rykova1, S Shuper1, M Shcherbakovsky1

  • 1Kharkiv National Medical University, Ukraine.

Georgian Medical News
|September 28, 2019
PubMed
Summary

Prolonged heat exposure significantly alters thyroid gland morphology in rats, reducing its overall functional activity. These findings highlight potential health risks associated with high temperatures in occupational settings.

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Area of Science:

  • Endocrinology
  • Environmental Health
  • Histology

Background:

  • Occupational exposure to high temperatures poses health risks.
  • Environmental factors, particularly heat, can impact thyroid function.
  • Thyroid gland structure and function are sensitive to external stressors.

Purpose of the Study:

  • To investigate the morphological adaptations of the thyroid gland in response to chronic heat exposure.
  • To assess the impact of prolonged hyperthermia on thyroid gland structure and cellular characteristics.

Main Methods:

  • Controlled laboratory study using 60 male Wistar rats.
  • Exposure to chronic moderate hyperthermia (42.0-43.1 °C) for 5 hours daily over 60 days.
  • Morphometric analysis of thyroid gland tissues at various time points during a rehabilitation period.

Main Results:

  • Significant changes in thyroid follicle morphology, including increased follicle and colloid area.
  • Reduced thyroid epithelium height and cellularity.
  • Decreased thyrocyte nuclear size and area, indicating reduced cellular activity.
  • Observed decrease in the functional-morphological index (FKI) and increase in the interfollicular space index (INK).

Conclusions:

  • Chronic hyperthermia leads to significant morphological alterations in the rat thyroid gland.
  • These changes are associated with a marked decrease in thyroid gland functional activity.
  • Findings suggest potential thyroid dysfunction under prolonged heat stress conditions.