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It's Time to Start Phenotyping Our Patients with Asthma
Hannah Duffey1, William C Anderson1
1Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, Box 518, Aurora, CO 80045, USA.
Immunology and Allergy Clinics of North America
|September 30, 2019
Summary
Precision medicine in pediatric asthma is advancing with new biologic therapies. This review highlights how phenotyping and biomarkers can guide tailored asthma treatments for better outcomes in children.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
- Pharmacogenomics
Background:
- Current pediatric asthma treatment guidelines lag behind recent therapeutic advancements.
- Biologics offer personalized treatment options for pediatric asthma patients.
- Phenotyping and biomarker identification are crucial for precision therapy.
Purpose of the Study:
- To review the current literature on phenotyping in pediatric asthma.
- To explore the utility of biomarkers in predicting asthma development and severity.
- To guide the selection of biologic therapies for difficult-to-control pediatric asthma.
Main Methods:
- Literature review of current studies on pediatric asthma phenotyping and biomarkers.
- Analysis of biomarker roles in asthma prediction, severity assessment, and treatment response.
- Evaluation of phenotypic data for guiding biologic therapy selection.
Main Results:
- Phenotyping and biomarkers enable more accurate asthma prediction and severity identification.
- Biomarkers forecast patient response to specific asthma therapies.
- Phenotypic data aids in selecting appropriate biologic agents for severe, uncontrolled pediatric asthma.
Conclusions:
- Phenotyping and biomarkers are essential for precision therapy in pediatric asthma.
- Tailored treatment strategies improve management of difficult-to-control asthma.
- Biomarker-guided biologic selection optimizes outcomes for severe pediatric asthma cases.
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