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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
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Animal models of emphysema
1Department of Intensive Care Unit, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Chinese Medical Journal
|October 1, 2019
Summary
Passive smoking in mice is a classic method for creating emphysema models. Pathomorphological indicators are crucial for evaluating these animal models of emphysema.
Area of Science:
- Pulmonary Medicine
- Toxicology
- Animal Models
Background:
- Chronic obstructive pulmonary disease (COPD) is a significant global health issue characterized by irreversible airflow limitation.
- Emphysema, a primary pathological feature of COPD, contributes to high mortality and substantial healthcare costs worldwide.
Purpose of the Study:
- To review established methods for creating and evaluating animal models of emphysema or COPD.
- To propose novel considerations for animal selection, modeling techniques, and evaluation criteria.
Main Methods:
- A comprehensive literature search was conducted on the PubMed database up to July 2019.
- Keywords included "emphysema," "model," and "animal," with a review of original articles and relevant literature.
Main Results:
- Passive smoking is identified as a classic method for inducing emphysema in animal models.
- Mice are deemed highly suitable for emphysema research.
- Pathomorphological indicators of lung tissue are considered the most critical parameters for evaluating model establishment, surpassing pulmonary function, airway inflammation, and oxidative stress indicators.
Conclusions:
- The mouse model induced by passive smoking is recognized as a classic animal model for emphysema.
- Pathomorphological indicators are paramount for assessing the successful establishment of emphysema animal models.
