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Updated: Jan 6, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition
Jun Liang1, Qingyue Gong2, Ying Li1
1Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science, University of Science and Technology of China, Hefei 230026, China. cltian@ustc.edu.cn.
Abstract:
Polyubiquitination with diverse linkages on histones provides another layer of accuracy and complexity for epigenetic regulation, which is rarely studied. Herein, K27 or K48-diubiquitin modified H2A analogues were chemically synthesized using thiirane linkers. These permitted in vitro binding studies suggested the plasticity of ubiquitin chains in 53BP1 recognition.
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