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[Effect of trypsin on suppressor cell formation and function in localized staphylococcal infection]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|March 1, 1985
Summary
Trypsin treatment of mice inoculated with staphylococci releases a factor that inhibits suppressor cells, thereby enhancing immune responses to sheep red blood cells (SRBC). This factor counteracts the immunosuppressive effects of lymphocytes from treated mice.
Area of Science:
- Immunology
- Cell Biology
Context:
- Investigating immune modulation in (CBA X C57BL)F1 mice.
- Utilizing sheep red blood cells (SRBC) and staphylococci (M-SRBC-S) models.
Purpose:
- To elucidate the mechanism by which splenic lymphocytes from M-SRBC-S mice suppress immune responses.
- To determine the effect of trypsin on lymphocyte function and immune suppression.
Summary:
- Splenic lymphocytes from M-SRBC-S mice suppressed SRBC-induced immune response in syngeneic recipients.
- Trypsin treatment of M-SRBC-S mice reduced lymphocyte-mediated suppression.
- Trypsin induced splenocytes to release an inhibitor of suppressor cell formation and function.
Impact:
- Identifies a trypsin-induced factor that modulates suppressor cell activity.
- Suggests a novel approach to counteract immunosuppression in specific contexts.
- Provides insights into the regulation of immune responses by suppressor cells.