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Updated: Jan 6, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Hormone Therapy for Transgender Adults.
1Callen-Lorde Community Health Center, 356 West 18th Street, New York, NY 10011, USA; Department of Medicine, NYU School of Medicine, New York, NY, USA.
Gender affirming hormone therapy (GAHT) is a safe and medically necessary treatment for transgender individuals. GAHT significantly improves mental health by reducing depression, anxiety, and gender dysphoria, aligning with best practice guidelines.
Area of Science:
- Endocrinology
- Psychiatry
- Gender Studies
Background:
- Transgender individuals experience a gender identity incongruent with their sex assigned at birth.
- Gender affirming hormone therapy (GAHT) is a crucial medical intervention for many transgender people.
- Established hormone protocols ensure the safety of GAHT.
Purpose of the Study:
- To highlight the medical necessity and safety of GAHT for transgender individuals.
- To underscore the positive mental health impacts of GAHT.
- To emphasize the importance of adhering to best practice guidelines for GAHT.
Main Methods:
- Review of current literature on gender affirming hormone therapy.
- Analysis of safety data within established hormone protocols.
- Evaluation of mental health outcomes associated with GAHT.
Main Results:
- GAHT, encompassing both feminizing and masculinizing regimens, is safe when administered according to established protocols.
- GAHT is linked to substantial improvements in mental health.
- Key benefits include significant reductions in depression, anxiety, and gender dysphoria.
Conclusions:
- Clinicians must be informed about current best practice guidelines for GAHT.
- GAHT is a safe and effective treatment for transgender individuals.
- Adherence to guidelines ensures optimal patient outcomes and well-being.
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