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Updated: Jan 6, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Hormone Therapy for Transgender Adults
1Callen-Lorde Community Health Center, 356 West 18th Street, New York, NY 10011, USA; Department of Medicine, NYU School of Medicine, New York, NY, USA.
Abstract:
Transgender people have a gender identity that differs from their sex assigned at birth. For many transgender individuals accessing gender affirming hormone therapy (GAHT) is an important and medically necessary step in their gender transition. Both feminizing and masculinizing regimens are safe when used within established hormone protocols and are associated with significant improvements in mental health outcomes, including reduction in depression, anxiety and gender dysphoria. Clinicians should be aware of the current best practice guidelines for initiating and maintaining patients on GAHT.
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