An Optical Surface Applicator for Intraoperative Photodynamic Therapy.
Sarah Chamberlain1, David Bellnier1, Sai Yendamuri2
1Department of Cell Stress Biology, Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), 665 Elm St., Buffalo, New York, 14203.
Lasers in Surgery and Medicine
|October 7, 2019
Summary
A novel optical surface applicator (OSA) improves light delivery for intraoperative photodynamic therapy (IO-PDT). This device ensures predictable light irradiance, enhancing therapeutic effectiveness for better tumor response.
Area of Science:
- Biomedical Optics
- Photodynamic Therapy
- Surgical Technology
Background:
- Intraoperative photodynamic therapy (IO-PDT) often uses handheld light sources with uncontrolled irradiance distribution.
- This variability impacts tissue and tumor response, limiting therapeutic efficacy.
- A need exists for precise light delivery in IO-PDT.
Purpose of the Study:
- To characterize a novel optical surface applicator (OSA).
- To evaluate the OSA's ability to deliver controlled light irradiance for IO-PDT.
- To assess the OSA's performance in a preclinical model.
Main Methods:
- Constructed an OSA using a flexible silicone mesh with diffusing optical fibers.
- Measured light irradiance distribution on the OSA surface and through tissue-mimicking phantoms.
- Tested the OSA's light delivery in swine using a photosensitizer (HPPH).
Main Results:
- OSA surface irradiance was non-uniform (128-346 mW/cm²).
- Irradiance uniformity improved significantly in phantoms (e.g., 39-153 mW/cm² at 3 mm depth).
- The OSA safely delivered therapeutic light doses in swine models.
Conclusions:
- The OSA provides predictable light irradiances for IO-PDT.
- This controlled delivery enables a well-defined therapeutic light dose.
- The OSA shows potential for enhancing IO-PDT efficacy.
