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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Related Experiment Video

Updated: Jan 6, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
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Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

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Gamma Delta T Cell Function in Ruminants.

Mariana Guerra-Maupome1, Jamison R Slate1, Jodi L McGill1

  • 1Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA.

The Veterinary Clinics of North America. Food Animal Practice
|October 9, 2019
PubMed
Summary

Gamma delta (γδ) T cells are crucial for host defense in ruminants. This review highlights their unique biology and protective roles against important infectious diseases.

Keywords:
BovineGamma delta T cellsImmune response to intracellular pathogensNonconventional T cellsRuminantVeterinary immunologyWorkshop cluster 1

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Area of Science:

  • Veterinary Immunology
  • Cellular Immunology
  • Ruminant Health

Background:

  • Gamma delta (γδ) T cells are a significant lymphocyte subset in peripheral blood and at epithelial barriers.
  • They possess unique antigen recognition, rapid effector functions, and tissue-specific homing capabilities.
  • These characteristics distinguish γδ T cells as a specialized immune effector population.

Purpose of the Study:

  • To review the current understanding of γδ T cell biology in ruminants.
  • To elucidate the critical roles of γδ T cells in combating infectious diseases relevant to ruminant health.
  • To highlight the veterinary and zoonotic importance of this nonconventional T cell population.

Main Methods:

  • Literature review of existing research on ruminant γδ T cells.
  • Analysis of functional characteristics and immune roles of γδ T cells.
  • Synthesis of data on protection against specific pathogens in ruminants.

Main Results:

  • γδ T cells are vital for innate and adaptive immunity in ruminants.
  • Their unique properties enable rapid responses to diverse pathogens.
  • Evidence supports their significant contribution to host defense against key ruminant infections.

Conclusions:

  • γδ T cells represent a critical component of the ruminant immune system.
  • Understanding their biology is essential for developing strategies against infectious diseases.
  • Further research into γδ T cell functions can advance veterinary and zoonotic disease control.