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Updated: Jan 6, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
Gamma Delta T Cell Function in Ruminants
Mariana Guerra-Maupome1, Jamison R Slate1, Jodi L McGill1
1Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA.
Abstract:
Gamma delta (γδ) T cells constitute a major lymphocyte population in peripheral blood and epithelial surfaces. They play nonredundant roles in host defense against diverse pathogens. Although γδ T cells share functional features with other cells of the immune system, their distinct methods of antigen recognition, rapid response, and tissue tropism make them a unique effector population. This review considers the current state of our knowledge on γδ T cell biology in ruminants and the important roles played by this nonconventional T cell population in protection against several infectious diseases of veterinary and zoonotic importance.
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