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Related Experiment Video

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Endoscopically Injectable Shear-Thinning Hydrogels Facilitating Polyp Removal.

Yan Pang1,2, Jinyao Liu2,3, Zaina L Moussa2

  • 1Department of Ophthalmology Ninth People's Hospital Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai Jiao Tong University School of Medicine Shanghai 200011 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 9, 2019
PubMed
Summary
This summary is machine-generated.

New shear-thinning hydrogels offer a superior submucosal injection solution for endoscopic mucosal resection. These biocompatible materials provide a long-lasting cushion, enhancing safety and efficiency in large lesion removal.

Keywords:
endoscopically injectableremoval of polypsshear‐thinning hydrogelssubmucosal

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Area of Science:

  • Gastroenterology and Endoscopy
  • Biomaterials Science

Background:

  • Submucosal elevation is crucial for endoscopic mucosal resection (EMR) of large lesions, aiding safe removal.
  • Traditional submucosal injection fluids like normal saline dissipate quickly, limiting their effectiveness.
  • Ideal injection fluids require injectability, biocompatibility, and sustained cushion formation.

Purpose of the Study:

  • To introduce and evaluate novel, endoscopically injectable shear-thinning hydrogels as improved submucosal injection fluids.
  • To assess the potential of these hydrogels for creating a stable submucosal cushion during EMR procedures.

Main Methods:

  • Development of shear-thinning hydrogels using biocompatible components.
  • Evaluation of hydrogel injectability and in-situ gelation properties.
  • Assessment of hydrogel performance as a submucosal cushion in a large animal model.

Main Results:

  • The novel shear-thinning hydrogels demonstrated excellent injectability and formed stable hydrogels upon injection.
  • These hydrogels provided a durable submucosal cushion, effectively separating mucosal and muscularis layers.
  • Successful application was validated through evaluation in a large animal model.

Conclusions:

  • Shear-thinning hydrogels represent a promising advancement in submucosal injection fluid technology.
  • Their unique properties offer enhanced cushion stability and longevity compared to conventional solutions.
  • These hydrogels are anticipated to significantly benefit endoscopic mucosal resection techniques.