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Folate-receptor 1 level in periodontal disease: a pilot study
Duygu Alkan1, Berrak Guven2, Cigdem Coskun Turer3
1Department of Periodontology, Faculty of Dentistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey. dtduygudurmus@gmail.com.
BMC Oral Health
|October 13, 2019
Summary
Gingival crevicular fluid (GCF) folate-receptor 1 (FOLR1) levels were elevated in periodontitis and gingivitis patients, but serum FOLR1 did not differ. GCF FOLR1 correlated with bleeding on probing, suggesting it may not be a reliable marker for periodontal disease monitoring.
Area of Science:
- Periodontology
- Biochemistry
- Immunology
Background:
- Periodontal diseases are inflammatory conditions affecting the gums and supporting structures of teeth.
- Folate-receptor 1 (FOLR1) plays a role in cellular processes and has been implicated in various inflammatory conditions.
Purpose of the Study:
- To investigate the levels of FOLR1 in gingival crevicular fluid (GCF) and serum across different periodontal health statuses.
- To determine the potential of FOLR1 as a biomarker for periodontal disease progression.
Main Methods:
- Recruitment of three groups: healthy (n=15), gingivitis (n=15), and chronic periodontitis (n=15).
- Assessment of clinical periodontal parameters: probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), and bleeding on probing (BOP).
- Quantification of FOLR1 levels in GCF and serum samples using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- FOLR1 levels in GCF were significantly higher in the gingivitis and periodontitis groups compared to the healthy group (p < 0.016).
- No significant differences in serum FOLR1 levels were observed among the study groups.
- A significant positive correlation was found between GCF FOLR1 levels and bleeding on probing (BOP) (p < 0.05).
Conclusions:
- Elevated GCF FOLR1 in periodontal disease suggests a localized inflammatory response.
- Serum FOLR1 does not appear to be a useful indicator for monitoring periodontal disease.
- Further research is needed to elucidate the precise role of folate and its receptors in the pathogenesis of periodontal disease.
