Analytical methods for determination of carbonyl compounds and nicotine in electronic No-Smoking aid refill solutions

The present investigation aimed to develop analytical methods to determine carbonyl compounds and nicotine and to assess the carbonyl compounds and nicotine concentrations in commercial refill solutions for electronic no-smoking aids (ENSAs). The analytical methods for carbonyl compounds and nicotine in refill solutions for ENSAs were developed and analyzed from 30 popular branded products by gas chromatography and liquid chromatography. They were then validated in terms of linearity of the calibration curve, limit of detection (LOD), limit of quantification (LOQ), accuracy (%), and precision (%). Further, the existence of carbonyl compounds and nicotine in the refill solutions for ENSAs was also evaluated. None of the samples contained nicotine, but carbonyl compounds were sensed in a concentration range from 0.9 to 11.65 μg/mL. Manufacturers of ENSA refill solutions have advertised no-smoking aids as less harmful than tobacco cigarettes and as free from harmful substances. However, carbonyl compounds were detected in all 30 samples. The investigation of ENSA refill solutions needs to be broadened to gain a better accepting of the existence of harmful materials in ENSA refill solutions and prevent unsuspected ill-health effects.