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Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

Clarissa Campbell1, Alexander Rudensky2

  • 1Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA; Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell Metabolism
|October 15, 2019
PubMed

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

Keywords:
metabolismregulatory T cellstissue homeostasis

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