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Updated: Jan 5, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
[Volemic resuscitation in acute care setting : which intravenous fluid ?]
Anh-Tho Huynh Dac1, Christophe Marti2, Sophie De Seigneux1
1Service de médecine interne générale, Département de médecine, HUG, 1211 Genève 14.
Abstract:
Crystalloid-type solutions are currently recommended for volume resuscitation. Although historically considered as « physiological saline », NaCl 0.9 % has a high concentration of sodium and chloride that can lead to metabolic acidosis and impaired renal function when large volumes are used. Recent evidence confirms that use of low-chloride crystalloids (so-called balanced solutions) could reduce the occurrence of renal failure and should be preferred during high volume resuscitation.
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