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Estrogen-secreting adrenocortical carcinoma
You Jeong1, Sung Chul Cho1, Hee Joon Cho1
1Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Yeungnam University Journal of Medicine
|October 18, 2019
Summary
This case report details an extremely rare estrogen-secreting adrenocortical carcinoma in a male patient. The successful treatment highlights potential management strategies for this rare endocrine malignancy.
Area of Science:
- Endocrinology
- Oncology
Background:
- Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence of 1-2 cases per million annually.
- While most ACCs secrete cortisol, aldosterone, or androgens, estrogen secretion is exceptionally rare.
Observation:
- A 53-year-old male presented with gynecomastia and abdominal discomfort.
- Radiological imaging identified a large retroperitoneal tumor (21×15.3×12 cm).
- Hormonal evaluation showed elevated estradiol, dehydroepiandrosterone sulfate, and cortisol levels.
Findings:
- The patient was diagnosed with a cortisol and estrogen-secreting adrenocortical carcinoma.
- Pathological examination confirmed ACC with a Weiss' score of 6.
- Post-surgical adjuvant radiotherapy was administered.
Implications:
- This case highlights the diagnostic and management challenges of rare hormone-secreting adrenocortical carcinomas.
- Successful surgical resection and adjuvant therapy led to a favorable outcome with no recurrence at 21 months.
- Further research into rare endocrine tumors is warranted to improve patient outcomes.
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