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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions.

Jin Li¹, Kanyu Xun¹, Ke Pei¹

¹Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

Journal of the American Chemical Society

|October 19, 2019

Summary

This summary is machine-generated.

Researchers engineered cell surfaces using 3D DNA scaffolds for stable cell connections. This DNA probe strategy enhances cell communication studies by improving membrane anchoring and target accessibility.

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Area of Science:

Biotechnology
Molecular Engineering
Cell Biology

Background:

Cell-cell interactions are vital for biological functions and are mediated by cell surface molecules.
Engineering cell surfaces for controlled interactions is challenging due to the dynamic nature of cell membranes.

Purpose of the Study:

To develop a novel strategy for engineering cell surfaces with DNA probes for controlled cell-cell interactions.
To enhance the stability and accessibility of membrane-anchored functional modules.

Main Methods:

Utilized three-dimensional (3D) amphiphilic pyramidal DNA as a scaffold for DNA probe construction.
Developed a biocompatible and versatile method for anchoring DNA probes to the cell surface.
Investigated the impact of DNA probe structure on membrane-anchoring stability and target accessibility.

Main Results:

The 3D pyramidal DNA probes demonstrated significantly higher membrane-anchoring stability (nearly 100-fold) compared to linear DNA constructs.
Achieved higher target accessibility (about 2.5-fold) with the pyramidal DNA probes.
Demonstrated specific, effective, and tunable cell-cell connections, highlighting the importance of proximity for intercellular communication.

Conclusions:

The developed DNA probe strategy offers a biocompatible, stable, and versatile platform for engineering cell surfaces.
This approach provides a powerful and designable nanoplatform for studying multicellular communication networks.
The findings underscore the potential of DNA nanotechnology in advancing cell engineering and intercellular communication research.