DNA repair genes: contributions to prostate cancer predisposition and aggressiveness
Julie Boyle1, Kathleen A Cooney
1Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
The Canadian Journal of Urology
|October 21, 2019
Abstract:
Germline pathogenic mutations in DNA repair genes have been linked to prostate cancer risk and aggressiveness. This observation was facilitated by tumor sequencing of men with advanced prostate cancer and has important implications for clinical management. In addition, cascade testing will identify at-risk individuals who should be assessed for cancer risk.
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