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An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Target-triggered, self-powered DNAzyme-MnO2 nanosystem: towards imaging microRNAs in living cells
Mei-Rong Cui1, Xiang-Ling Li1, Jing-Juan Xu1
1State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. xlli@nju.edu.cn xujj@nju.edu.cn.
Abstract:
A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme-MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.
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