Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion...

Area of Science:

• Neurology
• Psychiatry
• Hematology

Background:

• The pathophysiology of conversion disorder (CD) remains unclear.
• Inflammatory processes are implicated in many psychiatric disorders.
• This study investigates inflammation markers in CD patients.

Purpose of the Study:

• To compare routine hemogram values between CD patients and healthy controls.
• To assess inflammation levels in CD using hematological parameters.
• To identify potential diagnostic markers for CD.

Main Methods:

• Compared hematological parameters in 158 CD patients and 145 healthy controls.
• Utilized Mann-Whitney U-test and Student's t-test for group comparisons.
• Performed regression and receiver operating curve (ROC) analyses to identify predictors.

Main Results:

• Conversion disorder patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV).
• Lymphocyte levels were decreased in CD patients.
• Multivariate and ROC analyses identified MPV, RDW, and NLR as independent predictors of CD.

Conclusions:

• Conversion disorder is associated with an acute inflammatory process.
• MPV, RDW, and NLR can indicate inflammation in CD.
• Elevated RDW and MPV levels may serve as novel markers for CD diagnosis.