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Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion
Hasan Büyükaslan1, Mehmet Asoğlu2
1Department of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, Turkey.
Insights
Conversion disorder (CD) is linked to inflammation. Increased mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil-to-lymphocyte ratio (NLR) can help diagnose CD.
Area of Science:
- Neurology
- Psychiatry
- Hematology
Background:
- The pathophysiology of conversion disorder (CD) remains unclear.
- Inflammatory processes are implicated in many psychiatric disorders.
- This study investigates inflammation markers in CD patients.
Purpose of the Study:
- To compare routine hemogram values between CD patients and healthy controls.
- To assess inflammation levels in CD using hematological parameters.
- To identify potential diagnostic markers for CD.
Main Methods:
- Compared hematological parameters in 158 CD patients and 145 healthy controls.
- Utilized Mann-Whitney U-test and Student's t-test for group comparisons.
- Performed regression and receiver operating curve (ROC) analyses to identify predictors.
Main Results:
- Conversion disorder patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV).
- Lymphocyte levels were decreased in CD patients.
- Multivariate and ROC analyses identified MPV, RDW, and NLR as independent predictors of CD.
Conclusions:
- Conversion disorder is associated with an acute inflammatory process.
- MPV, RDW, and NLR can indicate inflammation in CD.
- Elevated RDW and MPV levels may serve as novel markers for CD diagnosis.
Background:
The pathophysiology of conversion disorder (CD) is still not fully established. Many psychiatric disorders are known to be associated with inflammatory processes. We aimed to compare the routine hemogram values of CD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups.
Methods:
This study was conducted with CD patients (n=158) and healthy controls (n=145). Routine hematological parameters were examined in each participant. Group comparisons were made with Mann-Whitney U-test and Student's t-test. Regression analysis and receiver operating curve (ROC) analysis were also performed for the analysis of independent predictors.
Results:
The comparisons revealed that while neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV) were significantly higher in CD group (P<0.05), lymphocyte was decreased in that group (P>0.05). Multivariate and ROC analyses showed MPV, RDW, and NLR as independent predictors (P<0.05). ROC curve showed that MPV values of 7.8 or above could predict the CD with 84% sensitivity and 85% specificity (area under curve [AUC]=0.878; 95% confidence interval [CI]: 0.817-0.939), RDW values of 11.0 or above could predict the CD with 82% sensitivity and 73% specificity (AUC=0.871; 95% CI: 0.815-0.926), and NLR values of 1.8 or above could predict the CD with 85% sensitivity and 78% specificity (AUC=0.865; 95% CI: 0.802-0.929).
Conclusion:
CD is related to the acute inflammatory process. MPV, RDW, and NLR can reflect this inflammation. These parameters could be used in differential diagnosis; increased RDW and MPV levels can be used as a novel marker in CD.
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