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Etanercept-associated Nephropathy.

Awais Ammar1, Hafiz Zafar Ahmed Mahmood1, Zainab Shahid2

  • 1Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

Cureus
|October 22, 2019
PubMed
Summary
This summary is machine-generated.

Tumor necrosis factor (TNF) inhibitors treat immune-mediated diseases but can rarely cause kidney damage. This case highlights etanercept-induced nephropathy, a rare complication of TNF inhibitor therapy.

Keywords:
acute kidney injuryanti tnfanti-tnf therapyetanerceptglomerulo nephritisrheumatoid arthritistnf inhibitortnf-tumor necrosis factortumor necrosis factor alpha (tnf alpha)

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Area of Science:

  • Immunology
  • Nephrology
  • Pharmacology

Background:

  • Anti-tumor necrosis factor (TNF) medications target TNF, a cytokine central to systemic inflammation.
  • These agents treat various rheumatic and immune-mediated diseases.
  • While effective, anti-TNF therapy carries potential risks, including rare renal complications.

Observation:

  • A patient presented with nausea and flu-like symptoms.
  • The patient was undergoing treatment with an anti-TNF medication.

Findings:

  • The patient was diagnosed with etanercept-induced nephropathy.
  • This represents a rare instance of renal complication attributed to anti-TNF therapy.

Implications:

  • Clinicians should consider drug-induced nephropathy in patients on anti-TNF agents presenting with renal symptoms.
  • This case underscores the importance of monitoring renal function in patients receiving TNF inhibitors.
  • Further research into the mechanisms of anti-TNF-induced kidney injury is warranted.