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A Disposable Pneumatic Microgripper for Cell Manipulation with Image-Based Force Sensing.

Benjamin Gursky1, Sebastian Bütefisch2, Monika Leester-Schädel3

  • 1Institute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany. benjamin.gursky@tu-braunschweig.de.

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Summary

This study introduces a cost-effective disposable microgripper for precise cell manipulation. It integrates a force sensor for controlled gripping, enabling applications like patch clamp on delicate cell aggregates.

Keywords:
SU-8image-based force sensormicrogripperpatch clamp techniquepneumatic actuation

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Cell Biology

Background:

  • Precise manipulation of biological samples, particularly cell aggregates, is crucial for techniques like patch clamp electrophysiology.
  • Existing microgripping technologies often face challenges with cost, complexity, and controlled force application in liquid environments.

Purpose of the Study:

  • To present a novel design for a single-use disposable pneumatic microgripper.
  • To integrate an optically readable force sensor for controlled gripping force.
  • To enable cost-effective batch microfabrication for cell manipulation in liquid environments.

Main Methods:

  • Microfabrication of a disposable gripper element using SU-8 and a single lithography mask.
  • Integration of a reusable gripper fixture and an optically readable force sensor.
  • Pneumatic actuation for gripper operation and force characterization.

Main Results:

  • Demonstrated cost-effective batch microfabrication by shifting complexity to reusable components.
  • Integrated force sensors exhibited good linearity and were examined separately.
  • The microgripper achieved variable gripping forces up to 5.7 mN in experiments.

Conclusions:

  • The developed disposable pneumatic microgripper offers a cost-effective solution for precise cell handling.
  • The integrated force sensor enables controlled gripping, suitable for sensitive biological applications.
  • This technology facilitates gripping cell aggregates, such as Langerhans islets, for electrophysiological measurements without causing damage.