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Updated: Jan 5, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

HMNPPID-human malignant neoplasm protein-protein interaction database.

Qingqing Li¹, Zhihao Yang², Zhehuan Zhao¹

¹College of Computer Science and Technology, Dalian University of Technology, Dalian, 116024, China.

|October 23, 2019

Summary

A new database, HMNPPID, catalogs protein-protein interactions (PPIs) for 171 human malignant neoplasms. This resource, with a visualization tool, aids researchers in understanding neoplasm biology and accelerates cancer research.

Keywords:

Database Human malignant neoplasms Protein–protein interactions

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Area of Science:

Biomedical Informatics
Molecular Biology
Oncology

Background:

Protein-protein interactions (PPIs) are crucial for understanding biological mechanisms.
PPIs in human malignant neoplasms offer insights into cancer biology.
A dedicated database for these specific PPIs is currently lacking.

Purpose of the Study:

To construct a comprehensive database of protein-protein interactions associated with human malignant neoplasms.
To develop a visualization tool for analyzing these interactions.

Main Methods:

Systematic extraction of PPI data from biomedical literature.
Curation and organization of interactions related to 171 types of human malignant neoplasms.
Development of the VisualPPI software for network visualization.

Main Results:

Construction of the Human Malignant Neoplasm Protein-Protein Interaction Database (HMNPPID).
HMNPPID contains PPI information for 171 kinds of human malignant neoplasms.
The VisualPPI program facilitates the analysis of neoplasm-specific PPI networks.

Conclusions:

HMNPPID serves as a valuable resource for researchers studying PPIs in human malignant neoplasms.
Availability of curated data accelerates research by reducing manual literature review.
Facilitates a deeper understanding of the molecular basis of neoplasms.