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Surface Tracking of Curcumin Amorphous Solid Dispersions Formulated by Binary Polymers.

Na Fan1, Tong Lu2, Jing Li2

  • 1Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.

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Summary
This summary is machine-generated.

Curcumin amorphous solid dispersions (Cur ASDs) were formulated using binary polymers. Hydroxypropyl methylcellulose E50 (HPMC) demonstrated superior excipient properties for Cur ASDs compared to polyvinylpyrrolidone K30 (PVP), showing enhanced drug release.

Keywords:
amorphous solid dispersionsbinary polymershydroxypropyl methylcellulosetautomeric curcumin

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Curcumin amorphous solid dispersions (Cur ASDs) are investigated to enhance curcumin bioavailability.
  • Binary polymer systems, including Eudragit EPO with polyvinylpyrrolidone K30 (EuD-PVP) and Eudragit EPO with hydroxypropyl methylcellulose E50 (EuD-HPMC), were employed as excipients.
  • Understanding the surface properties and molecular interactions of Cur ASDs is crucial for optimizing drug delivery.

Purpose of the Study:

  • To prepare and characterize curcumin amorphous solid dispersions (Cur ASDs) using binary polymer systems.
  • To investigate the molecular interactions and wetting properties of Cur ASDs.
  • To evaluate the drug release profiles and determine the optimal excipient for Cur ASD formulation.

Main Methods:

  • Preparation of Cur ASDs using Eudragit EPO combined with PVP K30 or HPMC E50.
  • Surface characterization using Infrared spectroscopy and in situ Raman imaging spectroscopy.
  • Analysis of molecular interactions and wetting properties via molecular docking modeling and contact angle measurements.
  • Assessment of cumulative drug release over time.

Main Results:

  • Cur ASDs formulated with EuD-HPMC exhibited significantly higher cumulative drug release (approximately 48%) compared to those with EuD-PVP (approximately 15%).
  • EuD-HPMC demonstrated a carrier-controlled wetting property, facilitating enhanced curcumin release.
  • EuD-PVP exhibited a drug-controlled wetting property, resulting in lower drug release.
  • Molecular interactions and surface properties were found to influence the release kinetics.

Conclusions:

  • Hydroxypropyl methylcellulose E50 (HPMC) is a superior excipient for curcumin amorphous solid dispersions (Cur ASDs) compared to polyvinylpyrrolidone K30 (PVP).
  • The wetting property of the excipient system plays a critical role in controlling curcumin release from ASDs.
  • The developed Cur ASDs, particularly with HPMC, hold potential for applications in the food and pharmaceutical industries to improve curcumin delivery.