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Rich-Club Analysis in Adults With ADHD Connectomes Reveals an Abnormal Structural Core Network.
Bing Wang1, Gongshu Wang1, Xin Wang1
1Taiyuan University of Technology, China.
Adults with attention-deficit hyperactivity disorder (ADHD) show altered brain connectomes, specifically a less dense rich-club network. This may explain differences in brain efficiency and functional dynamics compared to typical development.
Area of Science:
- Neuroscience
- Brain Imaging
- Connectomics
Background:
- Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder affecting adults.
- The brain's rich-club organization, crucial for efficient information processing, is not well understood in adult ADHD.
Purpose of the Study:
- To investigate abnormalities in the brain's rich-club connectome in adults with ADHD.
- To compare structural and functional brain connectivity between adults with ADHD and typically developing adults.
Main Methods:
- Diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) were employed.
- The study included 42 adults with ADHD and 59 typically developing adults.
Main Results:
- Adults with ADHD exhibited reduced rich-club density in key brain regions like the precuneus and insula.
- Lower global brain efficiency was observed in adults with ADHD, potentially due to diminished rich-club connections.
- Adults with ADHD showed stronger coupling between structural and functional connectivity.
Conclusions:
- Connectome abnormalities, characterized by reduced rich-club connectivity density, are present in adults with ADHD.
- Altered functional brain dynamics may accompany these structural connectome changes in ADHD.
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