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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
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Current overview on viroid-host interactions
Charith Raj Adkar-Purushothama1,2, Jean-Pierre Perreault2
1MYM Nutraceuticals Inc, Vancouver, British Columbia, Canada.
Wiley Interdisciplinary Reviews. RNA
|October 24, 2019
Summary
Viroids are plant pathogens that cause disease symptoms without coding for proteins. Recent research highlights viroid-derived small RNAs and host interactions in understanding viroid pathogenicity.
Area of Science:
- Plant Pathology
- Molecular Biology
- RNA Biology
Background:
- Viroids are small, circular, single-stranded RNA pathogens that cause plant diseases.
- Despite lacking protein-coding genes, viroids induce symptoms similar to plant viruses.
- The mechanisms underlying viroid-induced diseases and host interactions are not fully understood.
Purpose of the Study:
- To summarize current knowledge on viroid-host interactions.
- To simplify the complex biology of viroids for future research.
- To elucidate the role of viroid-derived small RNAs in pathogenicity.
Main Methods:
- Review of existing literature on viroid-host interactions.
- Analysis of molecular biology techniques and computational algorithms.
- Integration of findings on RNA silencing pathways and host factors.
Main Results:
- Viroid pathogenicity involves direct interaction with host factors.
- Viroid-derived small RNAs play a role in RNA silencing pathways.
- Complex interactions include host factors, viroid structure, and ribosomal stress.
Conclusions:
- Understanding viroid-host interactions is crucial for plant disease management.
- Advances in molecular biology and computational approaches are enhancing knowledge of viroid pathogenicity.
- Further research is needed to fully unravel the complexities of viroid biology.
Keywords:
gene silencingvd-sRNAviroid induced RNA silencingviroid structureviroid-host interactionsviroidsMore Related Videos
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