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Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

3.1K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
4.2K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.7K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
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Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymers02:34

Polymers

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

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Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids.

Xinfeng Tao1, Hui Chen2, Sylvain Trépout3

  • 1Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China and Chimie ParisTech, PSL Université Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France. min-hui.li@chimieparistech.psl.eu.

Chemical Communications (Cambridge, England)
|October 25, 2019
PubMed
Summary

New biocompatible polymersomes were created using unique block copolypeptoids. These nanoparticles exhibit aggregation-induced emission and strong fluorescence, making them promising for various applications.

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Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Development of advanced nanomaterials for biomedical applications is crucial.
  • Polymersomes offer versatile platforms due to their tunable properties and biocompatibility.
  • Aggregation-induced emission (AIE) is a desirable property for fluorescent probes and imaging agents.

Purpose of the Study:

  • To synthesize and characterize novel biocompatible polymersomes.
  • To investigate the aggregation-induced emission (AIE) properties of these polymersomes.
  • To evaluate the non-cytotoxicity and fluorescence of the nanoparticles in aqueous environments.

Main Methods:

  • Preparation of amphiphilic block copolypeptoids.
  • Modification of the hydrophobic block with tetraphenylethylene (TPE).
  • Characterization of polymersome formation and fluorescence properties.

Main Results:

  • Successfully synthesized amphiphilic block copolypeptoids with a TPE-modified hydrophobic block (poly(N-allylglycine)) and a hydrophilic polysarcosine block.
  • Polymersomes formed exhibited strong fluorescence emission in aqueous solution due to AIE.
  • The prepared nanoparticles demonstrated non-cytotoxic behavior.

Conclusions:

  • Novel biocompatible polymersomes with AIE properties were successfully prepared.
  • These polymersomes are suitable for aqueous environments and exhibit potential for bioimaging and drug delivery.
  • The combination of biocompatibility and AIE in polymersomes opens new avenues in nanomedicine.