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Updated: Jan 5, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Synthesis and Anti-mycobacterium Study on Halo-substituted 2-aryl oxyacetohydrazones
Vijay J Desale1,2, Suraj N Mali3, Hemchandra K Chaudhari3
1Department of Chemistry, N.B. Mehta Science College, Bordi, Dist. Palghar-401701, Maharashtra, India
Background:
The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day.
Objective:
The objective of this study is to highlight the need of developing shorter, simpler and tolerable drug regimens.
Methods:
In the present study, we synthesized various halo-substituted 2-aryloxyacetohydrazones via a series of reactions from halo-substituted phenols. All the compounds were characterized by using various spectroscopic methods, such as NMR, FT-IR, UV spectroscopy, etc. Results: All the synthesized hydrazones showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 μg/mL) against Mycobacteria tuberculosis, H37RV strain.
Conclusion:
Our results would pave a new way for the development of more effective Anti-TB agents in the future.
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