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Highly Tough Hydrogels with the Body Temperature-Responsive Shape Memory Effect.

Ruixue Liang1, Haojie Yu1, Li Wang1

  • 1State Key Laboratory of Chemical Engineering, Institute of Polymer and Polymerization Engineering, College of Chemical and Biological Engineering , Zhejiang University , Hangzhou 310027 , Zhejiang , China.

ACS Applied Materials & Interfaces
|October 29, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed tough, body temperature-responsive shape memory hydrogels (SMHs) for biomedical uses. These novel hydrogels demonstrate excellent shape memory and mechanical strength, paving the way for new applications.

Keywords:
body temperature responsivenesshigh mechanical performancehydrogelhydrogen bondshydrophobic interactionsshape memory effect

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Shape memory hydrogels (SMHs) are smart materials with tissue-like structures, ideal for biomedical applications.
  • Existing SMHs face challenges in achieving high mechanical strength and body temperature-responsiveness.
  • Developing robust and responsive SMHs is crucial for advancing smart material applications.

Purpose of the Study:

  • To develop a facile and scalable method for creating highly tough hydrogels with body temperature-responsive shape memory.
  • To investigate the synergistic effects of hydrophobic interactions and hydrogen bonding in hydrogel formulation.
  • To evaluate the potential of these hydrogels in biomedical applications, such as vascular occlusion plugs.

Main Methods:

  • Synthesized hydrogels using 2-Phenoxyethyl acrylate (PEA) as the hydrophobic monomer and acrylamide as the hydrophilic monomer.
  • Investigated the mechanical properties, including tensile strength and stretchability, at varying temperatures.
  • Assessed the shape memory behavior, focusing on shape fixity and shape recovery at body temperature.
  • Explored the application of the hydrogels as embolization plugs in in vitro vascular occlusion simulations.

Main Results:

  • The prepared hydrogels achieved a maximum tensile strength of 5.1 ± 0.16 MPa with good stretchability.
  • Mechanical strength demonstrated a significant dependence on temperature.
  • Hydrogels with 60 mol % PEA exhibited excellent body temperature-responsive shape memory, with nearly 100% shape fixity and recovery.
  • Preliminary in vitro tests showed promising performance as shape memory embolization plugs for vascular occlusion.

Conclusions:

  • A facile and scalable method for producing tough, body temperature-responsive shape memory hydrogels was successfully established.
  • The synergistic combination of hydrophobic interactions and hydrogen bonding is key to achieving desired material properties.
  • These advanced hydrogels show significant potential for biomedical applications, particularly in vascular occlusion therapies.