Use of Genome Editing Tools in Environmental Health Research

The nature and types of genome editing tools are rapidly expanding and becoming increasingly incorporated into research efforts aimed at understanding human disease. The majority of research involving genome editing has been driven by medical research, with a limited but increasing number of studies currently published in the field of environmental health and toxicology. This review aims to address this research gap by providing a high-level summary of current genome editing techniques and presenting examples of how some of these techniques have been used toxicologically to evaluate environmental exposure-induced disease. Specific strategies surrounding the evaluation of hazardous chemicals, chemical mechanism of action / adverse outcome pathways, and inter-individual response variability are also discussed to aid in the translation of genome editing methods towards toxicological and environmental health research.