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Updated: Jan 4, 2026
Circulating MicroRNA Quantification Using DNA-binding Dye Chemistry and Droplet Digital PCR
Published on: June 26, 2016
Digital quantitative detection of serum circulating miRNAs using dual-enhanced magnetobiosensors based on cascaded
Chunxue Liu1, Yayun An1, Yuanfu Zhang1
1Department of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China. xueqingwang1983@163.com hswang@lcu.edu.cn.
Abstract:
The tough challenges for the convenient and quantitative determination of circulating miRNAs (cmiRNAs) in the peripheral blood are low abundance, high interference and lack of direct digital readout. Here, we developed dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits, which integrate catalyzed hairpin assembly (CHA) with the hybridization chain reaction (HCR), for sensitive, portable and digital quantitative detection of circulating miRNAs in serum by a personal glucose meter (PGM).
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