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The Hamster Model of Sequential Oral Carcinogenesis: An Update
Christos Yapijakis1,2,3, Stefania Kalogera3, Veronica Papakosta2
1First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Hospital, Athens, Greece cyapi@med.uoa.gr.
In Vivo (Athens, Greece)
|October 31, 2019
Summary
The hamster model of sequential oral carcinogenesis is a valuable tool for studying oral cancer progression and testing new therapies. This animal model aids in understanding gene expression changes and evaluating potential treatments.
Area of Science:
- Oncology
- Animal Models
- Carcinogenesis
Background:
- Animal models are crucial for cancer research and preclinical trials.
- The hamster model of chemically induced sequential oral carcinogenesis was established to study multistep gene expression changes during cancer development.
Purpose of the Study:
- To review the utility of the hamster model in understanding oral cancer pathways.
- To highlight its application in biomarker evaluation and therapeutic strategy development.
Main Methods:
- Literature search of studies citing the hamster model of sequential oral carcinogenesis.
- Analysis of research utilizing this model for biomarker expression, chemoprevention, and therapeutic evaluation.
Main Results:
- The hamster model has been widely used to evaluate biomarkers.
- It has also been employed to test chemopreventive compounds and therapeutic interventions.
- Studies combine biomarker analysis with the assessment of anticancer effects of compounds.
Conclusions:
- The hamster model of sequential oral carcinogenesis is a versatile tool.
- It facilitates research in oral cancer cell biology, pathology, and therapeutics.
