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Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence
Ana L M Almeida1, Leopoldo A Pires1, Evelyn A Figueiredo2
1Department of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
Introduction:
We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment.
Methods:
Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire.
Results:
Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters.
Discussion:
The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population.
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