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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Radiation Modifiers.

Deborah E Citrin¹

¹Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 10 CRC, Room B2-3500, 10 Center Drive, Bethesda, MD 20892, USA.

Hematology/Oncology Clinics of North America

|November 1, 2019

Summary

This summary is machine-generated.

Radiation modifiers enhance cancer treatment by altering tissue response to radiation therapy. These agents, including sensitizers and protectors, show promise for improved clinical development through molecular tumor characterization.

Keywords:

Radiation modifier Radiation protector Radiation sensitizer Therapeutic ratio

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Area of Science:

Oncology
Radiation Oncology
Cancer Therapeutics

Background:

Radiation therapy is a cornerstone of cancer treatment.
Radiation modifiers are agents designed to modulate the effects of radiation on tumors and normal tissues.
Current radiation modifiers are largely investigational, with potential for future clinical application.

Purpose of the Study:

To describe various types of radiation modifiers.
To highlight the potential of molecular tumor characterization in advancing radiation modifier development.
To provide an overview of agents that enhance or protect against radiation effects.

Main Methods:

Review of existing literature on radiation modifiers.
Description of radiation sensitizers and their mechanisms.
Description of radioprotectors and their mechanisms.

Main Results:

Radiation sensitizers aim to increase tumor cell death post-irradiation by targeting tumor-specific molecular or physiological aspects.
Radioprotectors selectively mitigate damage to healthy tissues.
A diverse range of radiation modifiers have been identified and are under investigation.

Conclusions:

Radiation modifiers represent a promising area for enhancing cancer therapy efficacy and reducing side effects.
Further molecular characterization of tumors is crucial for the successful clinical development of these agents.
The described radiation modifiers offer potential avenues for personalized cancer treatment strategies.