Laboratory Assays of Immune Cell Function in Immunodeficiencies
1Allergy and Immunology Unit, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, COX 201, Boston, MA 02114, USA.
Clinics in Laboratory Medicine
|November 1, 2019
Summary
Laboratory assays of immune cell function are vital for diagnosing immune defects and understanding genetic mutations. These tests, combined with clinical evaluation, improve the diagnosis of complex immune pathophysiology.
Area of Science:
- Immunology
- Clinical Diagnostics
Background:
- Immune cell function assays are crucial for diagnosing immune deficiencies.
- Understanding immune cell function is key to identifying the impact of genetic mutations.
Purpose of the Study:
- To highlight the importance of laboratory assays in evaluating immune cell function.
- To emphasize the role of these assays in conjunction with clinical assessments for diagnosing immune defects.
Main Methods:
- Detailed patient history and physical examination.
- Laboratory assays assessing immune cell function.
- Analysis of genetic mutations and their functional impact.
Main Results:
- Laboratory assays provide essential data on immune cell function.
- These assays demonstrate the functional consequences of genetic mutations.
- Advances in diagnostics enhance the understanding of immune pathophysiology.
Conclusions:
- Laboratory assays of immune cell function are indispensable for diagnosing immune defects.
- Integrating functional assays with clinical data improves diagnostic accuracy.
- Ongoing advancements in diagnostic techniques are crucial for unraveling complex immune disorders.
