[Transcatheter treatment of tricuspid regurgitation]

Area of Science:

• Cardiology
• Interventional Cardiology
• Cardiac Surgery

Background:

• Tricuspid regurgitation (TR) is a severe cardiac condition associated with high mortality rates.
• Surgical correction for TR is underperformed due to significant patient risk.
• There is a critical unmet need for less invasive treatment options for TR.

Purpose of the Study:

• To review the current landscape of transcatheter tricuspid interventions.
• To outline the indications, contraindications, and necessary pre-procedural evaluations for these novel therapies.
• To detail the various percutaneous strategies currently in development for TR.

Main Methods:

• Review of existing literature and clinical data on transcatheter tricuspid repair and replacement.
• Analysis of preclinical and early clinical development of emerging technologies.
• Discussion of comprehensive patient evaluation protocols, including clinical status, comorbidities, TR severity, and cardiac anatomy.

Main Results:

• Several percutaneous technologies are in development, aiming to replicate surgical approaches targeting leaflets, annulus, or complete valve replacement.
• A thorough pre-procedural assessment is crucial for patient selection and determining the optimal transcatheter technique.
• The review covers a range of emerging strategies for TR treatment.

Conclusions:

• Transcatheter interventions offer a promising alternative for patients with severe tricuspid regurgitation who are poor surgical candidates.
• Careful patient selection and anatomical assessment are paramount for successful transcatheter tricuspid interventions.
• The field of percutaneous tricuspid valve treatment is rapidly evolving, with multiple technologies nearing clinical application.