Site-Tunable Csp-H Bonds Functionalization by Visible-Light-Induced Radical Translocation of N-Alkoxyphthalimides
Chuanyong Wang1, Yangyang Yu1, Wen-Long Liu1
1College of Chemistry and Chemical Engineering , Yangzhou University , 180 Siwangting Road , Yangzhou 225002 , China.
Abstract:
Site-tunable functionalization of C(sp3)-H bonds has been accomplished through radical translocation and cross-coupling. Upon irradiation with visible light, copper-based photocatalyst [Cu(Xantphos)(dmp)]BF4 enabled cross-coupling of N-alkoxyphthalimides with amino acid esters or amino acids to provide δ-C(sp3)-H alkylated alcohols (31 examples, up to 92% yield) with additive BNDHP or α-C(sp3)-H alkylated alcohols (18 examples, up to 86% yield) with additive DABCO in a highly regioselective fashion.
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