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[Hypervitaminosis B12. Our experience and a review]
Abrar-Ahmad Zulfiqar1, Emmanuel Andres1, Noel Lorenzo Villalba1
1Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France.
Medicina
|November 1, 2019
Summary
High vitamin B12 levels (hypervitaminemia B12) can indicate serious conditions like cancer or blood disorders. This finding, often underestimated, warrants further investigation into its diverse underlying causes.
Area of Science:
- Clinical Biochemistry
- Hematology
- Oncology
Background:
- Elevated serum vitamin B12 (cobalamin) is a clinically significant but often overlooked finding.
- Hypervitaminemia B12 has been associated with various serious medical conditions.
Purpose of the Study:
- To report on the diverse causes of hypervitaminemia B12.
- To review the existing literature and present institutional experience with this abnormality.
Main Methods:
- Literature review of studies reporting causes of elevated vitamin B12.
- Analysis of clinical data from patients with hypervitaminemia B12 (specific details not provided in abstract).
Main Results:
- Common associations include solid tumors (primary/metastatic) and hematological diseases (acute/chronic).
- Other identified causes encompass liver disorders, monoclonal gammopathy, renal failure, and autoimmune conditions.
- Less frequent causes include excessive vitamin B12 intake and transient hematological changes.
Conclusions:
- Hypervitaminemia B12 is an important indicator that should not be underestimated.
- The differential diagnosis for elevated vitamin B12 is broad, necessitating thorough clinical evaluation.
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