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Feed frame: The last processing step before the tablet compaction in pharmaceutical manufacturing.
Nobel O Sierra-Vega1, Rodolfo J Romañach2, Rafael Méndez1
1Department of Chemical Engineering, University of Puerto Rico at Mayaguez, PR 00681, United States.
International Journal of Pharmaceutics
|November 5, 2019
Summary
The feed frame is vital for pharmaceutical tablet manufacturing, impacting powder blend uniformity and tablet quality. This review examines powder flow, residence time, and paddle wheel design effects on tablet weight.
Area of Science:
- Pharmaceutical Manufacturing
- Powder Technology
- Process Engineering
Background:
- The feed frame is a critical component in pharmaceutical die filling.
- Accurate die filling ensures critical quality attributes of manufactured tablets.
- Recent advancements focus on real-time monitoring and understanding powder behavior within the feed frame.
Purpose of the Study:
- To review recent advances in understanding powder flow behavior within the feed frame.
- To analyze how operating conditions and design parameters affect powder residence time distribution.
- To highlight the impact of paddle wheel design and process parameters on tablet weight.
Main Methods:
- Literature review of recent advances in feed frame technology.
- Analysis of powder flow dynamics and residence time distribution.
- Investigation of process parameters and their influence on tablet weight.
Main Results:
- Powder flow behavior and residence time distribution are significantly influenced by operating conditions and design parameters.
- Paddle wheel design and feed frame process parameters directly affect tablet weight.
- Real-time monitoring of powder blend uniformity shows potential for Process Analytical Technology.
Conclusions:
- Optimizing feed frame design and operating conditions is crucial for consistent tablet manufacturing.
- Understanding powder flow and residence time is key to controlling tablet quality attributes.
- The feed frame plays a pivotal role in ensuring pharmaceutical product quality and process efficiency.
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