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Imaging Biological Samples with Optical Microscopy01:18

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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CMOS computational camera with a two-tap coded exposure image sensor for single-shot spatial-temporal compressive

Yi Luo, Jacky Jiang, Mengye Cai

    Optics Express
    |November 6, 2019
    PubMed
    Summary

    This study introduces a power-efficient CMOS computational camera using on-chip compressive sensing. The novel design enables spatial-temporally encoded exposure for high-speed video recovery without extra optical components.

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    Area of Science:

    • Computational Imaging
    • Electrical Engineering
    • Computer Vision

    Background:

    • Traditional cameras require high frame rates for high-speed imaging, leading to large data volumes.
    • Compressive sensing (CS) offers a way to capture signals below the Nyquist rate, but often requires external hardware.
    • Existing CS camera designs can be power-intensive and complex.

    Purpose of the Study:

    • To develop a power-efficient CMOS computational camera with integrated compressive sensing.
    • To demonstrate on-chip spatial-temporal coded exposure for high-speed video acquisition.
    • To enable reconstruction of high-speed videos from compressed data.

    Main Methods:

    • A CMOS image sensor with per-pixel programmable charge modulation was designed.
    • Each pixel incorporates a two-tap charge modulator and memory cells for exposure coding.
    • A proof-of-concept 128x128 pixel sensor was fabricated and tested for spatial-temporal coded exposure.

    Main Results:

    • The prototype camera achieved per-frame spatial-temporal coded exposure at 10 frames per second.
    • High-speed videos were successfully recovered after reconstruction from the compressed data.
    • The system demonstrated efficient operation without external optical modulators.

    Conclusions:

    • The proposed CMOS computational camera offers a power-efficient solution for compressive sensing applications.
    • On-chip integration of compressive sensing simplifies hardware and reduces power consumption.
    • This approach enables high-speed video recovery with a compact and efficient camera system.