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Updated: Jan 4, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Local surface plasmon resonance of gold nanoparticles as a correlative light and electron microscopy (CLEM) tag for
Tomohiro Haruta1, Keiko Hasumi1, Yuta Ikeda1
1Application Management Department, JEOL Ltd, 3-1-2 Musashino, Akishima, Tokyo, Japan.
Abstract:
In this study, we investigated use of local surface plasmon resonance (LSPR) of metal nanoparticles (NPs) as a correlative light and electron microscopy (CLEM) tag for biological samples. Gold NPs in ultra-thin sections for TEM revealed that LSPR could be observed by optical microscopy at sizes of 20 nm or larger. Gold NPs at sizes less than 20 nm could be observed using the gold enhancement method. Therefore, this CLEM tag could be applied to immunoelectron microscopy using this gold enhancement method.
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