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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Coronary Artery Disease IV: Preventive Measures01:26

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Related Experiment Video

Updated: Jan 4, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

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MIRKB: a myocardial infarction risk knowledge base.

Chaoying Zhan1, Manhong Shi1,2, Rongrong Wu1

  • 1Centre for Systems Biology, Soochow University, Suzhou 215006, China.

Database : the Journal of Biological Databases and Curation
|November 6, 2019
PubMed
Summary

Myocardial infarction (MI) is a leading cause of death. The Myocardial Infarction Risk Knowledge Base (MIRKB) compiles MI risk factors and models to aid research and prevention efforts.

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Area of Science:

  • Cardiovascular Disease Research
  • Biomedical Informatics

Background:

  • Myocardial infarction (MI) is a major global health concern with complex, incompletely understood causes.
  • Identifying individuals at high risk for MI is crucial for effective prevention strategies.

Purpose of the Study:

  • To introduce the Myocardial Infarction Risk Knowledge Base (MIRKB), a comprehensive resource for MI risk factors and models.
  • To facilitate systems biology-level understanding of MI etiology and progression.

Main Methods:

  • Data was collected from 4366 PubMed articles published before July 5, 2019.
  • The MIRKB database contains 8436 entries, including single factors, combined factors, and risk models.
  • Factors are categorized into molecular, imaging, physiological, clinical, environmental, lifestyle, and psychosocial types.

Main Results:

  • The MIRKB includes 7902 entries for 1847 single factors, 195 entries for 157 combined factors, and 339 entries for 174 risk models.
  • Detailed breakdown of single factors across categories: molecular (649), imaging (252), physiological (219), clinical (561), environmental (26), lifestyle (65), and psychosocial (75).

Conclusions:

  • The MIRKB serves as a valuable resource for researchers investigating the complex mechanisms of MI.
  • This knowledge base will support future systems-level analysis of MI development and progression.