Developing a Model of Care for Home Infusions of Natalizumab for People With Multiple Sclerosis

Timothy J Schultz1, Anne Thomas, Paul Georgiou

  • 1Adelaide Nursing School, University of Adelaide, Adelaide, South Australia, Australia (Drs Schultz and Cusack, Ms Juaton); Post Op Care at Home (Pty Ltd), McLaren Vale, South Australia, Australia (Ms Thomas); Royal Adelaide Hospital, Adelaide, South Australia, Australia (Mr Georgiou, Mr Webb, Ms Simon, and Dr Ravindran); Biogen Inc, Tokyo, Japan (Ms Naidoo); College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia (Dr Karnon). Timothy J. Schultz, PhD, is senior research fellow and postgraduate coordinator in Adelaide Nursing School. He is an interdisciplinary researcher who focuses on the role of nursing in health care delivery. His main areas of research are systematic reviews, health services, patient safety, and the implementation of evidence into practice. Anne Thomas, BSc, RN, is an experienced registered nurse and director of Post-Op Care At Home (Pty Ltd), which was subcontracted to deliver home infusions. She has extensive experience with the pharmaceutical industry, including delivering home infusions with Baxter Healthcare and companies throughout Australia. Paul Georgiou, MNsg(AcuteCare), RN, is the nurse unit manager at the Medical Day Treatment Unit, Royal Adelaide Hospital. This unit manages people with life-long chronic diseases as a referral service delivery by skilled nurses. Mr Georgiou is also a member of the Royal Australian Army Nursing Corps, with experience in operational and nonoperational roles. Lynette Cusack, PhD, MHA, RN, is an associate professor in the Adelaide Nursing School. Her research focus is on the contemporary role of the nurse in a range of different contexts, redefining models of practice, including impact on the health care system, interdisciplinary team, and patients' experience. Mahasen Juaton, MNsg, RN, is a master of clinical science (research) candidate at the Adelaide Nursing School. Lorraine Simon, MNsg, RN, is the assistant nurse unit manager at the Medical Day Treatment Unit at Royal Adelaide Hospital. Kerisha Naidoo, MPharm, MBA, is an employee of Biogen Inc, a multinational biotechnology company specializing in the discovery, development, and delivery of therapies for neurological diseases. She is the head of the medical excellence and operation team in Japan, leading data generation, medical operations, field medical excellence, and patient services functions. Kevin Webb, BNurs, RN, is a neurology nurse consultant at Royal Adelaide Hospital and the Queen Elizabeth Hospital. Jonathan Karnon, PhD, MSc, is a health economist at Flinders University. His main area of research is the use of economic evaluation to inform health service decision-making. Dr Karnon has developed and applied methods for the economic evaluations of health care technologies and services in Australia and the United Kingdom. Janakan Ravindran, MBBS, is a consultant neurologist at the Royal Adelaide and Lyell McEwin hospitals. He is currently the clinical lead for neuroimmunology at the Royal Adelaide Hospital and has particular subspecialty interests in multiple sclerosis and other neuroimmunological conditions, as well as peripheral neuromuscular disorders.

Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
450
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
525
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
201
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
636
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
261
Documentation in Long-Term and Home Healthcare Setting01:29

Documentation in Long-Term and Home Healthcare Setting

Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
1.4K