Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

9.7K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Cytokine and DNA Damage Response of Human Lung Tissue Models to Broad-Beam and Microbeam Radiotherapy.

Cells·2026
Same author

A fully automated workflow for the digital image analysis of the intestinal microcolony survival assay.

Scientific reports·2026
Same author

PEERing into the Future: Benchmarking the ANSTO Australian Synchrotron's Very-High-Energy Electron Linac for Ultra-High Dose-Rate, In Vivo FLASH Radiotherapy Research.

Cancers·2026
Same author

Targeting Lung Cancer Cell Motility Using Microbeam Radiation Therapy.

Cells·2026
Same author

A fasting-mimicking environment enhances procaspase-activating compound 1 in 2D and 3D glioma cell models.

Cell cycle (Georgetown, Tex.)·2026
Same author

Synchrotron-generated microbeams as a radiosurgical alternative for drug-resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy.

Epilepsia·2025

Related Experiment Video

Updated: Jan 4, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K

Technical advances in x-ray microbeam radiation therapy.

Stefan Bartzsch1,2, Stéphanie Corde3,4,5, Jeffrey C Crosbie6

  • 1Department of Radiation Oncology, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.

Physics in Medicine and Biology
|November 7, 2019
PubMed
Summary

Microbeam radiation therapy (MRT) uses synchrotron-based X-rays to deliver high doses to tumors while sparing normal tissue. Recent technical advancements are bringing this promising cancer treatment closer to clinical application.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Related Experiment Videos

Last Updated: Jan 4, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Biomedical Engineering

Background:

  • Microbeam radiation therapy (MRT) utilizes kilovoltage X-rays modulated by a multi-slit collimator to create high-dose peaks and low-dose valleys.
  • Pre-clinical studies suggest MRT offers a wider therapeutic window by reducing normal tissue damage at equivalent tumor control rates.
  • Potential applications extend beyond oncology to microsurgery and drug delivery enhancement.

Purpose of the Study:

  • To review technical developments in microbeam radiation therapy (MRT).
  • To discuss solutions for dosimetric validation, treatment planning, and safety in MRT.
  • To explore instrumentation at synchrotron facilities and alternative compact microbeam sources.

Main Methods:

  • Review of technical advancements in MRT instrumentation, including beam production and collimators.
  • Discussion of dosimetry techniques for high spatial resolution, low photon energies, and high dose rates.
  • Examination of dose calculation algorithms and the use of dose-enhancing nanoparticles.
  • Presentation of concepts for compact microbeam sources (e.g., inverse Compton scattering, carbon nanotube X-ray tubes).

Main Results:

  • Development of dosimetry techniques capable of handling high spatial resolution and dose rates up to 15,000 Gy/s.
  • Progress in dose calculation algorithms to address small voxel sizes and wide dose ranges.
  • Exploration of nanoparticles to overcome limited X-ray beam penetrability.
  • Maturation of treatment planning, dosimetry, and safety systems at synchrotrons.

Conclusions:

  • Practical solutions for most technical challenges in MRT have been achieved.
  • Advancements position MRT for initial veterinary and clinical studies.
  • MRT shows potential as an effective radiotherapy option for specific patient groups if clinical studies confirm pre-clinical findings.