Related Experiment Video
Updated: Jan 4, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
De-Intensification Of Blood Glucose Lowering Medication In People Identified As Being Over-Treated: A Mixed Methods
Huberta E Hart1,2, Kim Ditzel1, Guy E Rutten1
1Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Aim:
To evaluate if, one year after notification of possible overtreatment, diabetes care providers de-intensified glucose-lowering medications and to gain insight into the opinions and beliefs of both care providers and patients regarding de-intensification.
Methods:
Mixed methods using routine care data from five health-care centres in the Netherlands. Patient characteristics and medication prescription of patients, previously identified as possibly over-treated, were extracted from patients' medical records. Opinions of care providers were obtained through interviews. Patients received questionnaires about their diabetes treatment and were asked to participate in focus groups.
Results:
A total of 64 elderly patients with type 2 diabetes were previously identified as possibly over-treated and included; 57.8% male, median age 75 years (IQR=72-82), median diabetes duration 12 years (IQR=8-18). De-intensification was implemented in more than half (n=36) of them. Care providers preferred person-centred care above just setting general HbA1c target values, considering patient characteristics (such as comorbidity) and patient's preference. Patients valued glucose levels as most important in determining their treatment. Both patients and care providers felt that de-intensification should occur gradually.
Conclusion:
Treatment had been de-intensified in more than half of the patients (56.3%). Insight in reasons for not de-intensifying elderly patients is important since treatment for them can be "person-centred care". De-intensification is an iterative and time-intensive process.
Insights
More than half of elderly patients with type 2 diabetes had their glucose-lowering medications de-intensified after overtreatment notification. Both patients and providers favored gradual, person-centered care adjustments.
Area of Science:
- Endocrinology
- Geriatrics
- Pharmacology
Background:
- Overtreatment of type 2 diabetes in elderly patients is a concern.
- De-intensification of glucose-lowering medications requires understanding provider and patient perspectives.
Purpose of the Study:
- To assess medication de-intensification in elderly type 2 diabetes patients one year post-notification of possible overtreatment.
- To explore care provider and patient views on diabetes medication de-intensification.
Main Methods:
- Mixed-methods approach utilizing routine care data from five Dutch health-care centers.
- Patient medical records were reviewed for characteristics and medication prescriptions.
- Care provider interviews and patient questionnaires/focus groups gathered opinions and beliefs.
Main Results:
- De-intensification occurred in 56.3% (n=36) of 64 elderly patients with type 2 diabetes.
- Care providers prioritized person-centered care, considering patient specifics and preferences over strict HbA1c targets.
- Patients emphasized glucose levels' importance, with both groups preferring gradual de-intensification.
Conclusions:
- Over half of elderly patients with type 2 diabetes experienced medication de-intensification.
- Understanding reasons for non-de-intensification is crucial for implementing person-centered care.
- Diabetes medication de-intensification is an iterative and time-intensive process.
Related Concept Videos
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Therapeutic Drug Monitoring: Affecting Factors

