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Biopsy needle integrated with multi-modal physical/chemical sensor array.

Jaeho Park1, Yongrok Jeong1, Jayoung Kim2

  • 1Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea.

Biosensors & Bioelectronics
|November 8, 2019
PubMed
Summary
This summary is machine-generated.

A new biopsy needle features an integrated multi-modal sensor array measuring electrical conductivity, pH, and glucose. This innovation aims to enhance image-guided biopsies by providing real-time tissue information at the needle tip.

Keywords:
BiopsyElectrical conductivity sensorGlucose sensorReal-time cancer discriminationpH sensor

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Accurate tissue characterization during biopsy is crucial for diagnosis.
  • Existing biopsy techniques may lack real-time physical and chemical feedback.
  • Developing integrated sensing capabilities can improve procedural precision.

Purpose of the Study:

  • To develop and evaluate a biopsy needle integrated with a multi-modal sensor array.
  • To assess the sensor's ability to measure electrical conductivity, pH, and glucose concentration.
  • To demonstrate the potential of this integrated system for improving image-guided biopsies.

Main Methods:

  • Fabrication of a flexible sensor array (conductivity, pH, glucose) on a polyimide substrate.
  • Integration of the sensor array onto a biopsy needle using a pressure-sensitive adhesive.
  • Performance evaluation of the sensor within physiological ranges (conductivity, pH, glucose).
  • Testing of multi-modal sensing capabilities using hydrogel phantoms, solutions, and porcine liver tissue.

Main Results:

  • The flexible sensor array was successfully fabricated and integrated onto the biopsy needle.
  • The sensor accurately measured parameters within human physiological ranges.
  • Dual-modal and multi-modal sensing capabilities were demonstrated in various test samples.
  • The system showed potential for differentiating tissue types based on measured parameters.

Conclusions:

  • The developed biopsy needle with an integrated multi-modal sensor array is a promising tool.
  • Real-time physical and chemical sensing can provide valuable information during biopsy procedures.
  • This technology has the potential to increase the accuracy of image-guided biopsies by enabling real-time tissue characterization.