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Related Concept Videos

Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Protein Organization01:24

Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Protein and Protein Structures02:15

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Conservation of Protein Domains Over Different Proteins02:26

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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The Dundee Resource for Sequence Analysis and Structure Prediction.

Stuart A MacGowan1, Fábio Madeira1, Thiago Britto-Borges1

  • 1Division of Computational Biology, College of Life Sciences, University of Dundee, UK.

Protein Science : a Publication of the Protein Society
|November 12, 2019
PubMed
Summary
This summary is machine-generated.

The Dundee Resource for Sequence Analysis and Structure Prediction (DRSASP) offers web services for protein structure and sequence analysis. These tools aid researchers in predicting protein features and analyzing genetic data, with over 1.5 million jobs completed.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Structural Biology

Background:

  • The Barton Group at the University of Dundee provides the Dundee Resource for Sequence Analysis and Structure Prediction (DRSASP).
  • DRSASP is a collection of web services and computational resources for biological sequence and structure analysis.
  • Existing resources are continuously updated to incorporate new technologies and web standards.

Purpose of the Study:

  • To provide accessible web services for protein secondary structure prediction, solvent accessibility, multiple sequence alignment, and disorder prediction.
  • To integrate various bioinformatics tools, including JPred4 and JABAWS, into a unified platform.
  • To develop new resources for analyzing population genetic data in evolutionary and structural contexts.

Main Methods:

  • Utilizes web servers like JPred4 for secondary structure and solvent accessibility prediction.
  • Employs JABAWS for multiple sequence alignment, disorder prediction, and conservation analysis.
  • Integrates tools via APIs and the Jalview workbench for complex workflow composition.

Main Results:

  • DRSASP offers flagship services JPred4 and JABAWS 2.2.
  • Resources are accessible via web interfaces, APIs, and the Jalview workbench.
  • Over 1.5 million jobs have been processed by DRSASP services since 2016.

Conclusions:

  • DRSASP provides substantial computational resources for public use in sequence and structure prediction.
  • The platform facilitates the creation of interactive, multitool analysis workflows.
  • Ongoing development ensures DRSASP remains a valuable resource for bioinformatics research.