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[New developments in topical pharmaceuticals].

Johannes Wohlrab1

  • 1Institut für angewandte Dermatopharmazie, Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland. johannes.wohlrab@medizin.uni-halle.de.

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|November 13, 2019
PubMed
Summary
This summary is machine-generated.

Innovative topical preparations are advancing dermatological treatments. Future developments will focus on novel drug delivery systems, including small molecules, biologics, and RNA derivatives, for enhanced skin barrier function and inflammatory disease management.

Keywords:
Epicutaneous adminstrationPharmaceutical vehicle strategiesProphylaxisTherapyTopical drug administration

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Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Topical preparations are mainstays in dermatological therapy.
  • Recent years have seen limited new active ingredients but innovative formulation strategies.
  • The intrinsic effects of topical formulations are increasingly recognized.

Purpose of the Study:

  • To review recent innovations and future trends in topical pharmaceutical preparations.
  • To highlight advancements in drug delivery for dermatological conditions.
  • To explore novel strategies for skin barrier modulation and gene expression regulation.

Main Methods:

  • Review of current literature on topical pharmaceutical development.
  • Analysis of emerging galenic concepts and vehicle strategies.
  • Exploration of biotechnological and physicochemical advancements relevant to epicutaneous application.

Main Results:

  • Development of innovative galenic concepts and strategies for topical preparations.
  • Anticipation of new active ingredients, including small molecules and biologics, for topical delivery.
  • Emergence of novel strategies for skin barrier regulation, including RNA derivatives.

Conclusions:

  • The potential of epicutaneous application is being realized through advanced vehicle strategies.
  • Biotechnology and physical chemistry are crucial for future innovations in topical drug delivery.
  • Topical preparations will play an increasingly significant role in treating inflammatory diseases and beyond.